課程大綱：大數(shù)據(jù)科學(xué)與BD2K-LINCS數(shù)據(jù)協(xié)調(diào)和集成中心培訓(xùn)
The Library of Integrated Network-based Cellular Signatures (LINCS) Program Overview
This module provides an overview of the concept behind the LINCS program;
and tutorials on how to get started with using the LINCS L1000 dataset.
Metadata and Ontologies
This module includes a broad high level description of the concepts behind metadata
and ontologies and how these are applied to LINCS datasets.
Serving Data with APIs
In this module we explain the concept of accessing data through
an application programming interface (API).
Bioinformatics Pipelines
This module describes the important concept of a Bioinformatics pipeline.
The Harmonizome
This module describes a project that integrates many resources that contain knowledge about genes and proteins.
The project is called the Harmonizome,
and it is implemented as a web-server application available at: http://amp.pharm.mssm.edu/Harmonizome/
Data Normalization
This module describes the mathematical concepts behind data normalization.
Data Clustering
This module describes the mathematical concepts behind data clustering,
or in other words unsupervised learning - the identification
of patterns within data without considering the labels associated with the data.
Midterm Exam
The Midterm Exam consists of 45 multiple choice questions which covers modules 1-7.
Some of the questions may require you to perform some analysis
with the methods you learned throughout the course on new datasets.
Enrichment Analysis
This module introduces the important concept of performing gene set enrichment analyses.
Enrichment analysis is the process of querying gene sets from genomics
and proteomics studies against annotated gene sets collected from prior biological knowledge.
Machine Learning
This module describes the mathematical concepts of supervised machine learning,
the process of making predictions from examples
that associate observations/features/attribute with one or more properties that we wish to learn/predict.
Benchmarking
This module discusses how Bioinformatics pipelines can be compared and evaluated.
Interactive Data Visualization
This module provides programming examples on how
to get started with creating interactive web-based data visualization elements/figures.
Crowdsourcing Projects
This final module describes opportunities to work on LINCS related projects that go beyond the course.
Final Exam
The Final Exam consists of 60 multiple choice questions which covers all of the modules
of the course. Some of the questions may require you to perform some analysis with
the methods you learned throughout the course on new datasets.
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